TargetNet
P18089
Alpha-2B adrenergic receptor
Function
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.
Database Links
| Database | Links |
|---|---|
| UniProt | P18089 |
| PDB | 2CVA |
| BioGrid | 106660 |
| BindingDB | P18089 |
| DrugBank | DB00217, DB00484, DB04840, DB00696, DB00800, DB00226, DB01170, DB04948, DB00368, DB01392 |
| Guide to PHARMACOLOGY | 26 |
| PharmGKB | PA36 |
| KEGG | hsa:151 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 151 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.916 | 0.0039 |
| Accuracy | 0.8496 | 0.0049 |
| Sensitivity | 0.8401 | 0.0069 |
| Specificity | 0.8602 | 0.0068 |
| BEDROC | 0.9543 | 0.0164 |
| MCC Threshold | 0.4 | N/A |
| MCC | 0.7107 | N/A |
| F-score Threshold | 0.4 | N/A |
| F-score | 0.8699 | N/A |