TargetNet
P16753
Capsid scaffolding protein
Function
Capsid scaffolding protein acts as a scaffold protein by binding major capsid protein UL86 in the cytoplasm, inducing the nuclear localization of both proteins. Multimerizes in the nucleus such as protein UL86 forms the icosahedral T=16 capsid. Autocatalytic cleavage releases the assembly protein, and subsequently abolishes interaction with major capsid protein UL86. Cleavages products are evicted from the capsid before or during DNA packaging (By similarity).
Database Links
| Database | Links |
|---|---|
| UniProt | P16753 |
| PDB | 1CMV, 1ID4, 1IEC, 1IED, 1IEF, 1IEG, 1JQ6, 1JQ7, 1LAY, 1NJT, 1NJU, 1NKK, 1NKM, 1WPO, 2WPO |
| BioGrid | Not available |
| BindingDB | P16753 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | Not available |
| BioCyc | Not available |
| Entrez Gene (GeneID) | Not available |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9434 | 0.0047 |
| Accuracy | 0.902 | 0.0093 |
| Sensitivity | 0.9149 | 0.012 |
| Specificity | 0.8894 | 0.015 |
| BEDROC | 0.9692 | 0.0161 |
| MCC Threshold | 0.418 | N/A |
| MCC | 0.7958 | N/A |
| F-score Threshold | 0.418 | N/A |
| F-score | 0.8997 | N/A |