TargetNet
P16581
E-selectin
Function
Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.
Database Links
| Database | Links |
|---|---|
| UniProt | P16581 |
| PDB | 1ESL, 1G1T, 1KJA |
| BioGrid | 112301 |
| BindingDB | P16581 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA35640 |
| KEGG | hsa:6401 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 6401 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.983 | 0.0061 |
| Accuracy | 0.9325 | 0.0082 |
| Sensitivity | 0.9192 | 0.017 |
| Specificity | 0.9437 | 0.0101 |
| BEDROC | 0.9998 | 8.5058 × 10-5 |
| MCC Threshold | 0.368 | N/A |
| MCC | 0.8816 | N/A |
| F-score Threshold | 0.368 | N/A |
| F-score | 0.9365 | N/A |