TargetNet
P16257
Translocator protein
Function
Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells (By similarity).
Database Links
| Database | Links |
|---|---|
| UniProt | P16257 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P16257 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | rno:24230 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 24230 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.991 | 0.0011 |
| Accuracy | 0.965 | 0.0032 |
| Sensitivity | 0.9678 | 0.0054 |
| Specificity | 0.9624 | 0.0027 |
| BEDROC | 0.9934 | 0.0031 |
| MCC Threshold | 0.508 | N/A |
| MCC | 0.9382 | N/A |
| F-score Threshold | 0.508 | N/A |
| F-score | 0.9674 | N/A |