TargetNet
P16184
Dihydrofolate reductase
Function
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Database Links
| Database | Links |
|---|---|
| UniProt | P16184 |
| PDB | 1CD2, 1DAJ, 1DYR, 1E26, 1KLK, 1LY3, 1LY4, 1S3Y, 1VJ3, 2CD2, 2FZH, 2FZI, 3CD2, 3NZ6, 3NZ9, 3NZA, 3NZB, 3NZC, 3TD8, 4CD2, 4G8Z, 4IXE, 4IXF, 4IXG |
| BioGrid | Not available |
| BindingDB | P16184 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | Not available |
| BioCyc | Not available |
| Entrez Gene (GeneID) | Not available |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.956 | 0.0031 |
| Accuracy | 0.9034 | 0.0046 |
| Sensitivity | 0.9138 | 0.0075 |
| Specificity | 0.8918 | 0.0073 |
| BEDROC | 0.9984 | 5.6892 × 10-4 |
| MCC Threshold | 0.632 | N/A |
| MCC | 0.8186 | N/A |
| F-score Threshold | 0.536 | N/A |
| F-score | 0.9124 | N/A |