TargetNet
P15538
Cytochrome P450 11B1, mitochondrial
Function
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.
Database Links
| Database | Links |
|---|---|
| UniProt | P15538 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P15538 |
| DrugBank | DB00648 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA133 |
| KEGG | hsa:1584 |
| BioCyc | MetaCyc:HS08547-MONOMER |
| Entrez Gene (GeneID) | 1584 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9895 | 0.0031 |
| Accuracy | 0.9575 | 0.0045 |
| Sensitivity | 0.9603 | 0.0023 |
| Specificity | 0.9551 | 0.0085 |
| BEDROC | 0.9988 | 6.8798 × 10-4 |
| MCC Threshold | 0.546 | N/A |
| MCC | 0.9267 | N/A |
| F-score Threshold | 0.546 | N/A |
| F-score | 0.9598 | N/A |