TargetNet
P15121
Aldose reductase
Function
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Database Links
| Database | Links |
|---|---|
| UniProt | P15121 |
| PDB | 1ABN, 1ADS, 1AZ1, 1AZ2, 1EF3, 1EL3, 1IEI, 1MAR, 1PWL, 1PWM, 1T40, 1T41, 1US0, 1X96, 1X97, 1X98, 1XGD, 1Z3N, 1Z89, 1Z8A, 2ACQ, 2ACR, 2ACS, 2ACU, 2AGT, 2DUX, 2DUZ, 2DV0, 2F2K, 2FZ8, 2FZ9, 2FZB, 2FZD, 2HV5, 2HVN, 2HVO, 2I16, 2I17, 2IKG, 2IKH, 2IKI, 2IKJ, 2INE, 2INZ, 2IPW, 2IQ0, 2IQD, 2IS7, 2ISF, 2J8T, 2NVC, 2NVD, 2PD5, 2PD9, 2PDB, 2PDC, 2PDF, 2PDG, 2PDH, 2PDI, 2PDJ, 2PDK, 2PDL, 2PDM, 2PDN, 2PDP, 2PDQ, 2PDU, 2PDW, 2PDX, 2PDY, 2PEV, 2PF8, 2PFH, 2PZN, 2QXW, 2R24, 3BCJ, 3DN5, 3G5E, 3GHR, 3GHS, 3GHT, 3GHU, 3LBO, 3LD5, 3LEN, 3LEP, 3LQG, 3LQL, 3LZ3, 3LZ5, 3M0I, 3M4H, 3M64, 3MB9, 3MC5, 3ONB, 3ONC, 3P2V, 3Q65, 3Q67, 3RX2, 3RX3, 3RX4, 3S3G, 3T42, 3U2C, 3V35, 3V36, 4GCA, 4GQ0, 4JIR |
| BioGrid | 106732 |
| BindingDB | P15121 |
| DrugBank | DB00157, DB00605 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA24675 |
| KEGG | hsa:231 |
| BioCyc | MetaCyc:HS01502-MONOMER |
| Entrez Gene (GeneID) | 231 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9603 | 0.0036 |
| Accuracy | 0.8992 | 0.0056 |
| Sensitivity | 0.8861 | 0.0092 |
| Specificity | 0.911 | 0.0058 |
| BEDROC | 0.9891 | 0.0038 |
| MCC Threshold | 0.448 | N/A |
| MCC | 0.821 | N/A |
| F-score Threshold | 0.376 | N/A |
| F-score | 0.9074 | N/A |