TargetNet
P15056
Serine/threonine-protein kinase B-raf
Function
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway.
Database Links
| Database | Links |
|---|---|
| UniProt | P15056 |
| PDB | 1UWH, 1UWJ, 2FB8, 2L05, 3C4C, 3D4Q, 3IDP, 3II5, 3NY5, 3OG7, 3PPJ, 3PPK, 3PRF, 3PRI, 3PSB, 3PSD, 3Q4C, 3Q96, 3SKC, 3TV4, 3TV6, 4DBN, 4E26, 4E4X, 4EHE, 4EHG, 4FC0, 4FK3, 4G9C, 4G9R, 4H58, 4JVG, 4KSP, 4KSQ, 4MBJ |
| BioGrid | 107141 |
| BindingDB | P15056 |
| DrugBank | DB00398 |
| Guide to PHARMACOLOGY | 1943 |
| PharmGKB | PA25408 |
| KEGG | hsa:673 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 673 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9678 | 0.0013 |
| Accuracy | 0.9146 | 0.0027 |
| Sensitivity | 0.8901 | 0.0045 |
| Specificity | 0.9361 | 0.0048 |
| BEDROC | 0.9988 | 2.9067 × 10-4 |
| MCC Threshold | 0.498 | N/A |
| MCC | 0.8251 | N/A |
| F-score Threshold | 0.492 | N/A |
| F-score | 0.9055 | N/A |