5-hydroxytryptamine receptor 2A
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
Database | Links |
---|---|
UniProt | P14842 |
PDB | 4OAJ |
BioGrid | 248227 |
BindingDB | P14842 |
DrugBank | Not available |
Guide to PHARMACOLOGY | 6 |
PharmGKB | Not available |
KEGG | rno:29595 |
BioCyc | Not available |
Entrez Gene (GeneID) | 29595 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9635 | 0.0015 |
Accuracy | 0.9169 | 0.0025 |
Sensitivity | 0.9327 | 0.004 |
Specificity | 0.9009 | 0.0044 |
BEDROC | 0.9744 | 0.0038 |
MCC Threshold | 0.496 | N/A |
MCC | 0.8307 | N/A |
F-score Threshold | 0.496 | N/A |
F-score | 0.9173 | N/A |