TargetNet
P14780
Matrix metalloproteinase-9
Function
May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
Database Links
| Database | Links |
|---|---|
| UniProt | P14780 |
| PDB | 1GKC, 1GKD, 1ITV, 1L6J, 1LKG, 2OVX, 2OVZ, 2OW0, 2OW1, 2OW2, 4H1Q, 4H2E, 4H3X, 4H82, 4HMA |
| BioGrid | 110461 |
| BindingDB | P14780 |
| DrugBank | DB01296, DB00786, DB01017, DB00641 |
| Guide to PHARMACOLOGY | 1633 |
| PharmGKB | PA30889 |
| KEGG | hsa:4318 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 4318 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9825 | 9.0758 × 10-4 |
| Accuracy | 0.9564 | 0.002 |
| Sensitivity | 0.956 | 0.0038 |
| Specificity | 0.9568 | 0.002 |
| BEDROC | 0.9933 | 0.004 |
| MCC Threshold | 0.51 | N/A |
| MCC | 0.9183 | N/A |
| F-score Threshold | 0.504 | N/A |
| F-score | 0.9596 | N/A |