TargetNet
P14600
Substance-P receptor
Function
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
Database Links
| Database | Links |
|---|---|
| UniProt | P14600 |
| PDB | Not available |
| BioGrid | 246930 |
| BindingDB | P14600 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 360 |
| PharmGKB | Not available |
| KEGG | rno:24807 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 24807 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9455 | 0.0033 |
| Accuracy | 0.8735 | 0.0035 |
| Sensitivity | 0.8969 | 0.0079 |
| Specificity | 0.8523 | 0.0054 |
| BEDROC | 0.9696 | 0.0043 |
| MCC Threshold | 0.658 | N/A |
| MCC | 0.7815 | N/A |
| F-score Threshold | 0.578 | N/A |
| F-score | 0.884 | N/A |