TargetNet
P14555
Phospholipase A2, membrane associated
Function
Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides.
Database Links
| Database | Links |
|---|---|
| UniProt | P14555 |
| PDB | 1AYP, 1BBC, 1DB4, 1DB5, 1DCY, 1J1A, 1KQU, 1KVO, 1N28, 1N29, 1POD, 1POE, 2GNY, 3U8B, 3U8D, 3U8H, 3U8I |
| BioGrid | 111337 |
| BindingDB | P14555 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 1417 |
| PharmGKB | PA270 |
| KEGG | hsa:5320 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5320 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.945 | 0.0045 |
| Accuracy | 0.8907 | 0.0072 |
| Sensitivity | 0.8846 | 0.013 |
| Specificity | 0.8962 | 0.0114 |
| BEDROC | 0.9784 | 0.0073 |
| MCC Threshold | 0.536 | N/A |
| MCC | 0.7902 | N/A |
| F-score Threshold | 0.454 | N/A |
| F-score | 0.8901 | N/A |