P14416

D(2) dopamine receptor

Function

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity).

Database Links

Database	Links
UniProt	P14416
PDB	1I15, 2YOU
BioGrid	108147
BindingDB	P14416
DrugBank	DB01063, DB00915, DB00714, DB01238, DB01200, DB00490, DB00248, DB01038, DB00477, DB01239, DB00568, DB00363, DB01184, DB00450, DB00696, DB00875, DB00623, DB04842, DB00502, DB01235, DB00589, DB00408, DB00933, DB01233, DB00805, DB01618, DB00334, DB01267, DB01186, DB00850, DB01100, DB00413, DB00433, DB00420, DB01069, DB00777, DB01224, DB00409, DB00734, DB00268, DB06144, DB00391, DB00372, DB00679, DB00752, DB00831, DB00508, DB00246, DB01624
Guide to PHARMACOLOGY	215
PharmGKB	PA27478
KEGG	hsa:1813
BioCyc	Not available
Entrez Gene (GeneID)	1813

Chemical Space of the Positive Compounds

Model Performance Metrics

Metric	Mean Value	Standard Deviation
AUC	0.9674	6.87 × 10^-4
Accuracy	0.9188	0.0021
Sensitivity	0.9283	0.0026
Specificity	0.9095	0.0027
BEDROC	0.982	0.0018
MCC Threshold	0.498	N/A
MCC	0.8377	N/A
F-score Threshold	0.498	N/A
F-score	0.919	N/A

Downloads

R Model Object

Random Forest model object (.RData)

Positive Set

SMILES string + affinity value (.tsv)