TargetNet
P14324
Farnesyl pyrophosphate synthase
Function
Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Database Links
| Database | Links |
|---|---|
| UniProt | P14324 |
| PDB | 1YQ7, 1YV5, 1ZW5, 2F7M, 2F89, 2F8C, 2F8Z, 2F92, 2F94, 2F9K, 2OPM, 2OPN, 2QIS, 2RAH, 2VF6, 3B7L, 3CP6, 3N1V, 3N1W, 3N3L, 3N45, 3N46, 3N49, 3N5H, 3N5J, 3N6K, 3RYE, 3S4J, 4DEM, 4GA3, 4H5C, 4H5D, 4H5E, 4JVJ, 4L2X |
| BioGrid | 108517 |
| BindingDB | P14324 |
| DrugBank | DB00630, DB00710, DB00282, DB00884, DB00399 |
| Guide to PHARMACOLOGY | 644 |
| PharmGKB | PA28075 |
| KEGG | hsa:2224 |
| BioCyc | MetaCyc:ENSG00000160752-MONOMER |
| Entrez Gene (GeneID) | 2224 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9697 | 0.003 |
| Accuracy | 0.9463 | 0.0046 |
| Sensitivity | 0.9534 | 0.0073 |
| Specificity | 0.94 | 0.0051 |
| BEDROC | 0.9705 | 0.0169 |
| MCC Threshold | 0.614 | N/A |
| MCC | 0.8884 | N/A |
| F-score Threshold | 0.614 | N/A |
| F-score | 0.9401 | N/A |