TargetNet
P14174
Macrophage migration inhibitory factor
Function
Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti- inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
Database Links
| Database | Links |
|---|---|
| UniProt | P14174 |
| PDB | 1CA7, 1CGQ, 1GCZ, 1GD0, 1GIF, 1LJT, 1MIF, 1P1G, 2OOH, 2OOW, 2OOZ, 3B9S, 3CE4, 3DJH, 3DJI, 3HOF, 3IJG, 3IJJ, 3JSF, 3JSG, 3JTU, 3L5P, 3L5R, 3L5S, 3L5T, 3L5U, 3L5V, 3SMB, 3SMC, 3U18, 4ETG, 4EUI, 4EVG, 4F2K, 4GRN, 4GRO, 4GRP, 4GRQ, 4GRR, 4GRU, 4GUM |
| BioGrid | 110428 |
| BindingDB | P14174 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA30819 |
| KEGG | hsa:4282 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 4282 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.7894 | 0.0146 |
| Accuracy | 0.7039 | 0.0152 |
| Sensitivity | 0.7398 | 0.0278 |
| Specificity | 0.6635 | 0.0121 |
| BEDROC | 0.8316 | 0.0608 |
| MCC Threshold | 0.352 | N/A |
| MCC | 0.5 | N/A |
| F-score Threshold | 0.352 | N/A |
| F-score | 0.7869 | N/A |