TargetNet
P14061
Estradiol 17-beta-dehydrogenase 1
Function
Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.
Database Links
| Database | Links |
|---|---|
| UniProt | P14061 |
| PDB | 1A27, 1BHS, 1DHT, 1EQU, 1FDS, 1FDT, 1FDU, 1FDV, 1FDW, 1I5R, 1IOL, 1JTV, 1QYV, 1QYW, 1QYX, 3DEY, 3DHE, 3HB4, 3HB5, 3KLM, 3KLP, 3KM0 |
| BioGrid | 109525 |
| BindingDB | P14061 |
| DrugBank | DB00157 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA29478 |
| KEGG | hsa:3292 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 3292 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9651 | 0.0027 |
| Accuracy | 0.9375 | 0.0068 |
| Sensitivity | 0.95 | 0.0097 |
| Specificity | 0.9252 | 0.0064 |
| BEDROC | 0.9417 | 0.023 |
| MCC Threshold | 0.324 | N/A |
| MCC | 0.8812 | N/A |
| F-score Threshold | 0.324 | N/A |
| F-score | 0.9412 | N/A |