TargetNet
P13945
Beta-3 adrenergic receptor
Function
Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
Database Links
| Database | Links |
|---|---|
| UniProt | P13945 |
| PDB | 2CDW |
| BioGrid | 106664 |
| BindingDB | P13945 |
| DrugBank | DB00368, DB00960, DB00571 |
| Guide to PHARMACOLOGY | 30 |
| PharmGKB | PA24598 |
| KEGG | hsa:155 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 155 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9934 | 5.8348 × 10-4 |
| Accuracy | 0.9765 | 0.0015 |
| Sensitivity | 0.984 | 0.0024 |
| Specificity | 0.9684 | 0.0013 |
| BEDROC | 0.9982 | 0.0024 |
| MCC Threshold | 0.426 | N/A |
| MCC | 0.9515 | N/A |
| F-score Threshold | 0.426 | N/A |
| F-score | 0.9769 | N/A |