TargetNet
P13922
Bifunctional dihydrofolate reductase-thymidylate synthase
Function
Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.
Database Links
| Database | Links |
|---|---|
| UniProt | P13922 |
| PDB | 1J3I, 1J3J, 1J3K, 3DG8, 3DGA |
| BioGrid | Not available |
| BindingDB | P13922 |
| DrugBank | DB01131, DB00205 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | Not available |
| BioCyc | Not available |
| Entrez Gene (GeneID) | Not available |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9627 | 0.0067 |
| Accuracy | 0.8936 | 0.0106 |
| Sensitivity | 0.8981 | 0.0188 |
| Specificity | 0.8881 | 0.0115 |
| BEDROC | 0.9996 | 2.5217 × 10-4 |
| MCC Threshold | 0.416 | N/A |
| MCC | 0.8062 | N/A |
| F-score Threshold | 0.416 | N/A |
| F-score | 0.9151 | N/A |