TargetNet
P13866
Sodium/glucose cotransporter 1
Function
Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.
Database Links
| Database | Links |
|---|---|
| UniProt | P13866 |
| PDB | Not available |
| BioGrid | 112414 |
| BindingDB | P13866 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 915 |
| PharmGKB | PA308 |
| KEGG | hsa:6523 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 6523 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.899 | 0.0107 |
| Accuracy | 0.8063 | 0.0109 |
| Sensitivity | 0.8552 | 0.0166 |
| Specificity | 0.7454 | 0.0179 |
| BEDROC | 0.9927 | 0.0046 |
| MCC Threshold | 0.26 | N/A |
| MCC | 0.637 | N/A |
| F-score Threshold | 0.26 | N/A |
| F-score | 0.8502 | N/A |