TargetNet
P13726
Tissue factor
Function
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Database Links
| Database | Links |
|---|---|
| UniProt | P13726 |
| PDB | 1AHW, 1BOY, 1DAN, 1FAK, 1J9C, 1JPS, 1NL8, 1O5D, 1TFH, 1UJ3, 1W0Y, 1W2K, 1WQV, 1WSS, 1WTG, 1WUN, 1WV7, 1Z6J, 2A2Q, 2AEI, 2AER, 2B7D, 2B8O, 2C4F, 2CEF, 2CEH, 2CEZ, 2CFJ, 2EC9, 2F9B, 2FIR, 2FLB, 2FLR, 2HFT, 2PUQ, 2ZP0, 2ZWL, 2ZZU, 3ELA, 3TH2, 3TH3, 3TH4 |
| BioGrid | 108451 |
| BindingDB | P13726 |
| DrugBank | DB00036 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA158 |
| KEGG | hsa:2152 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 2152 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9638 | 0.0033 |
| Accuracy | 0.9314 | 0.0022 |
| Sensitivity | 0.9254 | 0.0077 |
| Specificity | 0.9382 | 0.0069 |
| BEDROC | 0.9991 | 0.0011 |
| MCC Threshold | 0.436 | N/A |
| MCC | 0.8694 | N/A |
| F-score Threshold | 0.436 | N/A |
| F-score | 0.9391 | N/A |