Integrin alpha-4
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
Database | Links |
---|---|
UniProt | P13612 |
PDB | 3V4P, 3V4V, 4HKC |
BioGrid | 109883 |
BindingDB | P13612 |
DrugBank | DB00108 |
Guide to PHARMACOLOGY | 2443 |
PharmGKB | PA29940 |
KEGG | hsa:3676 |
BioCyc | Not available |
Entrez Gene (GeneID) | 3676 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9729 | 0.0018 |
Accuracy | 0.927 | 0.0031 |
Sensitivity | 0.9293 | 0.0054 |
Specificity | 0.9244 | 0.0037 |
BEDROC | 0.9963 | 0.0039 |
MCC Threshold | 0.43 | N/A |
MCC | 0.8687 | N/A |
F-score Threshold | 0.43 | N/A |
F-score | 0.9408 | N/A |