TargetNet
P13516
Acyl-CoA desaturase 1
Function
Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA.
Database Links
| Database | Links |
|---|---|
| UniProt | P13516 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P13516 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | mmu:20249 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 20249 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.986 | 0.0018 |
| Accuracy | 0.9598 | 0.0026 |
| Sensitivity | 0.9555 | 0.0039 |
| Specificity | 0.9636 | 0.002 |
| BEDROC | 0.9978 | 0.0017 |
| MCC Threshold | 0.366 | N/A |
| MCC | 0.9469 | N/A |
| F-score Threshold | 0.366 | N/A |
| F-score | 0.9718 | N/A |