TargetNet
P13497
Bone morphogenetic protein 1
Function
Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX.
Database Links
| Database | Links |
|---|---|
| UniProt | P13497 |
| PDB | 3EDG, 3EDH |
| BioGrid | 107117 |
| BindingDB | P13497 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA25377 |
| KEGG | hsa:649 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 649 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9968 | 0.0021 |
| Accuracy | 0.9817 | 0.004 |
| Sensitivity | 0.9901 | 0.0035 |
| Specificity | 0.9724 | 0.0065 |
| BEDROC | 0.9999 | 1.1962 × 10-4 |
| MCC Threshold | 0.572 | N/A |
| MCC | 0.9651 | N/A |
| F-score Threshold | 0.572 | N/A |
| F-score | 0.9834 | N/A |