TargetNet
P12822
Angiotensin-converting enzyme
Function
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity).
Database Links
| Database | Links |
|---|---|
| UniProt | P12822 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P12822 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | Not available |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 100009274 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9513 | 0.0121 |
| Accuracy | 0.9152 | 0.0149 |
| Sensitivity | 0.9017 | 0.0148 |
| Specificity | 0.9281 | 0.0199 |
| BEDROC | 0.9907 | 0.0064 |
| MCC Threshold | 0.486 | N/A |
| MCC | 0.849 | N/A |
| F-score Threshold | 0.486 | N/A |
| F-score | 0.9204 | N/A |