TargetNet
P12821
Angiotensin-converting enzyme
Function
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
Database Links
| Database | Links |
|---|---|
| UniProt | P12821 |
| PDB | 1O86, 1O8A, 1UZE, 1UZF, 2C6F, 2C6N, 2IUL, 2IUX, 2OC2, 2XY9, 2XYD, 2YDM, 3BKK, 3BKL, 3L3N, 3NXQ, 4APH, 4APJ, 4BXK, 4C2N, 4C2O, 4C2P, 4C2Q, 4C2R, 4CA5, 4CA6 |
| BioGrid | 108004 |
| BindingDB | P12821 |
| DrugBank | DB00542, DB01197, DB01089, DB00584, DB00492, DB00722, DB00691, DB00790, DB00881, DB00178, DB01180, DB01348, DB00519 |
| Guide to PHARMACOLOGY | 1613 |
| PharmGKB | PA139 |
| KEGG | hsa:1636 |
| BioCyc | MetaCyc:HS08412-MONOMER |
| Entrez Gene (GeneID) | 1636 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9647 | 0.0025 |
| Accuracy | 0.9176 | 0.0054 |
| Sensitivity | 0.9361 | 0.0063 |
| Specificity | 0.8967 | 0.0059 |
| BEDROC | 0.9908 | 0.0043 |
| MCC Threshold | 0.468 | N/A |
| MCC | 0.8312 | N/A |
| F-score Threshold | 0.468 | N/A |
| F-score | 0.9222 | N/A |