TargetNet
P12527
Arachidonate 5-lipoxygenase
Function
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
Database Links
| Database | Links |
|---|---|
| UniProt | P12527 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P12527 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | rno:25290 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 25290 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9458 | 0.0018 |
| Accuracy | 0.8883 | 0.0038 |
| Sensitivity | 0.8904 | 0.0044 |
| Specificity | 0.8862 | 0.0047 |
| BEDROC | 0.9858 | 0.0028 |
| MCC Threshold | 0.43 | N/A |
| MCC | 0.7779 | N/A |
| F-score Threshold | 0.43 | N/A |
| F-score | 0.8933 | N/A |