TargetNet
P12268
Inosine-5'-monophosphate dehydrogenase 2
Function
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Database Links
| Database | Links |
|---|---|
| UniProt | P12268 |
| PDB | 1B3O, 1NF7, 1NFB |
| BioGrid | 109828 |
| BindingDB | P12268 |
| DrugBank | DB00688, DB01024, DB00157 |
| Guide to PHARMACOLOGY | 2625 |
| PharmGKB | PA29863 |
| KEGG | hsa:3615 |
| BioCyc | MetaCyc:HS11242-MONOMER |
| Entrez Gene (GeneID) | 3615 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9873 | 8.2289 × 10-4 |
| Accuracy | 0.9493 | 0.004 |
| Sensitivity | 0.9506 | 0.0049 |
| Specificity | 0.9482 | 0.0039 |
| BEDROC | 0.9939 | 0.0033 |
| MCC Threshold | 0.314 | N/A |
| MCC | 0.904 | N/A |
| F-score Threshold | 0.314 | N/A |
| F-score | 0.9491 | N/A |