Cyclin-dependent kinase 4
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Database | Links |
---|---|
UniProt | P11802 |
PDB | 1LD2, 2W96, 2W99, 2W9F, 2W9Z, 3G33 |
BioGrid | 107454 |
BindingDB | P11802 |
DrugBank | Not available |
Guide to PHARMACOLOGY | 1976 |
PharmGKB | PA102 |
KEGG | hsa:1019 |
BioCyc | Not available |
Entrez Gene (GeneID) | 1019 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9614 | 0.0015 |
Accuracy | 0.9103 | 0.0031 |
Sensitivity | 0.9193 | 0.0065 |
Specificity | 0.8998 | 0.0041 |
BEDROC | 0.9976 | 0.0023 |
MCC Threshold | 0.524 | N/A |
MCC | 0.8204 | N/A |
F-score Threshold | 0.414 | N/A |
F-score | 0.9165 | N/A |