TargetNet
P11712
Cytochrome P450 2C9
Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S- warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Database Links
| Database | Links |
|---|---|
| UniProt | P11712 |
| PDB | 1OG2, 1OG5, 1R9O |
| BioGrid | 107937 |
| BindingDB | P11712 |
| DrugBank | DB01418, DB00969, DB01118, DB00025, DB00673, DB00559, DB00821, DB01136, DB00482, DB01242, DB00250, DB00705, DB00967, DB00304, DB00586, DB00736, DB00749, DB00196, DB00472, DB00712, DB01095, DB00176, DB00983, DB01241, DB01381, DB01016, DB00222, DB01067, DB01018, DB00327, DB01050, DB00458, DB01029, DB01026, DB00448, DB00678, DB01283, DB00470, DB00784, DB00814, DB00532, DB00916, DB01110, DB00683, DB00471, DB00731, DB00220, DB00622, DB01192, DB00213, DB00617, DB00946, DB00252, DB00175, DB00908, DB00503, DB00412, DB01104, DB00203, DB01015, DB00870, DB00675, DB00469, DB00342, DB01124, DB00214, DB01361, DB00580, DB00177, DB00582, DB00682, DB00549, DB00744 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA126 |
| KEGG | hsa:1559 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1559 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.835 | 0.0023 |
| Accuracy | 0.7497 | 0.0064 |
| Sensitivity | 0.7394 | 0.0118 |
| Specificity | 0.76 | 0.0087 |
| BEDROC | 0.9584 | 0.0074 |
| MCC Threshold | 0.562 | N/A |
| MCC | 0.5109 | N/A |
| F-score Threshold | 0.4 | N/A |
| F-score | 0.77 | N/A |