TargetNet
P11511
Aromatase
Function
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Database Links
| Database | Links |
|---|---|
| UniProt | P11511 |
| PDB | 1TQA, 3EQM, 3S79, 3S7S, 4GL5, 4GL7, 4KQ8 |
| BioGrid | Not available |
| BindingDB | P11511 |
| DrugBank | DB00357, DB01217, DB00286, DB01406, DB00255, DB00990, DB01006, DB00894, DB00624 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA27091 |
| KEGG | hsa:1588 |
| BioCyc | MetaCyc:HS06413-MONOMER |
| Entrez Gene (GeneID) | 1588 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9627 | 0.0024 |
| Accuracy | 0.9004 | 0.004 |
| Sensitivity | 0.9035 | 0.0079 |
| Specificity | 0.8978 | 0.0026 |
| BEDROC | 0.9904 | 0.0051 |
| MCC Threshold | 0.608 | N/A |
| MCC | 0.7967 | N/A |
| F-score Threshold | 0.574 | N/A |
| F-score | 0.8859 | N/A |