Muscarinic acetylcholine receptor M1
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Database | Links |
---|---|
UniProt | P11229 |
PDB | Not available |
BioGrid | 107550 |
BindingDB | P11229 |
DrugBank | DB00517, DB00572, DB00767, DB00245, DB01019, DB00810, DB00354, DB00411, DB00748, DB00185, DB00771, DB00785, DB01176, DB00979, DB00942, DB01151, DB00804, DB01231, DB00366, DB00392, DB01148, DB00986, DB00725, DB00424, DB00332, DB00940, DB01403, DB00462, DB00340, DB01233, DB00334, DB01062, DB00383, DB00219, DB01085, DB00670, DB00387, DB00420, DB01069, DB00782, DB00777, DB01103, DB00747, DB01591, DB00202, DB00372, DB01036, DB00505, DB00508, DB00376, DB00209 |
Guide to PHARMACOLOGY | 13 |
PharmGKB | PA26484 |
KEGG | hsa:1128 |
BioCyc | Not available |
Entrez Gene (GeneID) | 1128 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9119 | 0.0025 |
Accuracy | 0.8382 | 0.0046 |
Sensitivity | 0.8777 | 0.006 |
Specificity | 0.7896 | 0.0074 |
BEDROC | 0.9747 | 0.0052 |
MCC Threshold | 0.528 | N/A |
MCC | 0.6857 | N/A |
F-score Threshold | 0.524 | N/A |
F-score | 0.8609 | N/A |