Muscarinic acetylcholine receptor M2
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.
Database | Links |
---|---|
UniProt | P10980 |
PDB | Not available |
BioGrid | Not available |
BindingDB | P10980 |
DrugBank | Not available |
Guide to PHARMACOLOGY | 14 |
PharmGKB | Not available |
KEGG | rno:81645 |
BioCyc | Not available |
Entrez Gene (GeneID) | 102551851, 81645 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9329 | 0.0014 |
Accuracy | 0.8731 | 0.0044 |
Sensitivity | 0.8433 | 0.0045 |
Specificity | 0.8995 | 0.0092 |
BEDROC | 0.9934 | 0.0075 |
MCC Threshold | 0.4 | N/A |
MCC | 0.7722 | N/A |
F-score Threshold | 0.4 | N/A |
F-score | 0.8816 | N/A |