TargetNet
P10828
Thyroid hormone receptor beta
Function
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Database Links
| Database | Links |
|---|---|
| UniProt | P10828 |
| PDB | 1BSX, 1N46, 1NAX, 1NQ0, 1NQ1, 1NQ2, 1NUO, 1Q4X, 1R6G, 1XZX, 1Y0X, 2J4A, 2NLL, 2PIN, 3D57, 3GWS, 3IMY, 3JZC |
| BioGrid | 112924 |
| BindingDB | P10828 |
| DrugBank | DB00451, DB00279 |
| Guide to PHARMACOLOGY | 589 |
| PharmGKB | PA36508 |
| KEGG | hsa:7068 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 7068 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9827 | 0.0011 |
| Accuracy | 0.9523 | 0.0034 |
| Sensitivity | 0.9563 | 0.0048 |
| Specificity | 0.9481 | 0.0069 |
| BEDROC | 0.9994 | 2.8793 × 10-4 |
| MCC Threshold | 0.482 | N/A |
| MCC | 0.9166 | N/A |
| F-score Threshold | 0.482 | N/A |
| F-score | 0.9595 | N/A |