TargetNet
P10827
Thyroid hormone receptor alpha
Function
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Database Links
| Database | Links |
|---|---|
| UniProt | P10827 |
| PDB | 1NAV, 2H77, 2H79, 3HZF, 3ILZ, 3JZB |
| BioGrid | 112923 |
| BindingDB | P10827 |
| DrugBank | DB00451, DB00279 |
| Guide to PHARMACOLOGY | 588 |
| PharmGKB | PA36507 |
| KEGG | hsa:7067 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 7067 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9753 | 0.0061 |
| Accuracy | 0.926 | 0.0077 |
| Sensitivity | 0.9418 | 0.007 |
| Specificity | 0.9078 | 0.011 |
| BEDROC | 0.9967 | 0.0067 |
| MCC Threshold | 0.59 | N/A |
| MCC | 0.8854 | N/A |
| F-score Threshold | 0.576 | N/A |
| F-score | 0.946 | N/A |