Apoptosis regulator Bcl-2
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Database | Links |
---|---|
UniProt | P10415 |
PDB | 1G5M, 1GJH, 1YSW, 2O21, 2O22, 2O2F, 2W3L, 2XA0, 4AQ3, 4IEH, 4LVT, 4LXD, 4MAN |
BioGrid | 107068 |
BindingDB | P10415 |
DrugBank | DB01248, DB01073, DB01065, DB01229, DB01367 |
Guide to PHARMACOLOGY | Not available |
PharmGKB | PA25302 |
KEGG | hsa:596 |
BioCyc | Not available |
Entrez Gene (GeneID) | 596 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9364 | 0.0038 |
Accuracy | 0.891 | 0.0062 |
Sensitivity | 0.8392 | 0.0087 |
Specificity | 0.9363 | 0.0055 |
BEDROC | 0.9886 | 0.0083 |
MCC Threshold | 0.45 | N/A |
MCC | 0.7894 | N/A |
F-score Threshold | 0.434 | N/A |
F-score | 0.8846 | N/A |