TargetNet
P10275
Androgen receptor
Function
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Database Links
| Database | Links |
|---|---|
| UniProt | P10275 |
| PDB | 1E3G, 1GS4, 1T5Z, 1T63, 1T65, 1XJ7, 1XOW, 1XQ3, 1Z95, 2AM9, 2AMA, 2AMB, 2AO6, 2AX6, 2AX7, 2AX8, 2AX9, 2AXA, 2HVC, 2OZ7, 2PIO, 2PIP, 2PIQ, 2PIR, 2PIT, 2PIU, 2PIV, 2PIW, 2PIX, 2PKL, 2PNU, 2Q7I, 2Q7J, 2Q7K, 2Q7L, 2YHD, 2YLO, 2YLP, 2YLQ, 2Z4J, 3B5R, 3B65, 3B66, 3B67, 3B68, 3BTR, 3L3X, 3L3Z, 3RLJ, 3RLL, 3V49, 3V4A, 3ZQT, 4HLW |
| BioGrid | 106862 |
| BindingDB | P10275 |
| DrugBank | DB01128, DB04839, DB00858, DB01216, DB01185, DB00499, DB00984, DB00665, DB00621, DB00624 |
| Guide to PHARMACOLOGY | 628 |
| PharmGKB | PA57 |
| KEGG | hsa:367 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 367 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9782 | 9.7916 × 10-4 |
| Accuracy | 0.9442 | 0.0016 |
| Sensitivity | 0.9415 | 0.0026 |
| Specificity | 0.9466 | 0.0022 |
| BEDROC | 0.9933 | 0.0023 |
| MCC Threshold | 0.434 | N/A |
| MCC | 0.8945 | N/A |
| F-score Threshold | 0.434 | N/A |
| F-score | 0.9446 | N/A |