TargetNet
P09960
Leukotriene A-4 hydrolase
Function
Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.
Database Links
| Database | Links |
|---|---|
| UniProt | P09960 |
| PDB | 1GW6, 1H19, 1HS6, 1SQM, 2R59, 2VJ8, 3B7R, 3B7S, 3B7T, 3B7U, 3CHO, 3CHP, 3CHQ, 3CHR, 3CHS, 3FH5, 3FH7, 3FH8, 3FHE, 3FTS, 3FTU, 3FTV, 3FTW, 3FTX, 3FTY, 3FTZ, 3FU0, 3FU3, 3FU5, 3FU6, 3FUD, 3FUE, 3FUF, 3FUH, 3FUI, 3FUJ, 3FUK, 3FUL, 3FUM, 3FUN, 3U9W, 4DPR |
| BioGrid | 110226 |
| BindingDB | P09960 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 1395 |
| PharmGKB | PA24345 |
| KEGG | hsa:4048 |
| BioCyc | MetaCyc:HS03372-MONOMER |
| Entrez Gene (GeneID) | 4048 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9685 | 0.0021 |
| Accuracy | 0.9185 | 0.0064 |
| Sensitivity | 0.9294 | 0.0096 |
| Specificity | 0.9069 | 0.0082 |
| BEDROC | 0.9988 | 3.1655 × 10-4 |
| MCC Threshold | 0.466 | N/A |
| MCC | 0.8271 | N/A |
| F-score Threshold | 0.466 | N/A |
| F-score | 0.9172 | N/A |