TargetNet
P09958
Furin
Function
Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.
Database Links
| Database | Links |
|---|---|
| UniProt | P09958 |
| PDB | Not available |
| BioGrid | 111082 |
| BindingDB | P09958 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 2366 |
| PharmGKB | PA32894 |
| KEGG | hsa:5045 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5045 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9922 | 0.0012 |
| Accuracy | 0.9739 | 0.0051 |
| Sensitivity | 0.9763 | 0.0043 |
| Specificity | 0.9716 | 0.0071 |
| BEDROC | 0.9976 | 0.0054 |
| MCC Threshold | 0.422 | N/A |
| MCC | 0.9542 | N/A |
| F-score Threshold | 0.422 | N/A |
| F-score | 0.977 | N/A |