TargetNet
P09917
Arachidonate 5-lipoxygenase
Function
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
Database Links
| Database | Links |
|---|---|
| UniProt | P09917 |
| PDB | 2ABV, 3O8Y, 3V92, 3V98, 3V99 |
| BioGrid | 106741 |
| BindingDB | P09917 |
| DrugBank | DB00711, DB00741, DB01097, DB00179, DB00939, DB01017, DB00471, DB01103, DB00163, DB00744 |
| Guide to PHARMACOLOGY | 1385 |
| PharmGKB | PA46 |
| KEGG | hsa:240 |
| BioCyc | MetaCyc:HS00336-MONOMER |
| Entrez Gene (GeneID) | 240 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9763 | 0.0015 |
| Accuracy | 0.9282 | 0.0031 |
| Sensitivity | 0.9245 | 0.0048 |
| Specificity | 0.9315 | 0.0044 |
| BEDROC | 0.9968 | 0.0011 |
| MCC Threshold | 0.436 | N/A |
| MCC | 0.8639 | N/A |
| F-score Threshold | 0.436 | N/A |
| F-score | 0.9281 | N/A |