Poly [ADP-ribose] polymerase 1
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitement to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.
Database | Links |
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UniProt | P09874 |
PDB | 1UK0, 1UK1, 1WOK, 2COK, 2CR9, 2CS2, 2DMJ, 2JVN, 2L30, 2L31, 2RCW, 2RD6, 2RIQ, 3GJW, 3GN7, 3L3L, 3L3M, 3OD8, 3ODA, 3ODC, 3ODE, 4AV1, 4DQY, 4GV7, 4HHY, 4HHZ, 4L6S |
BioGrid | 106652 |
BindingDB | P09874 |
DrugBank | Not available |
Guide to PHARMACOLOGY | Not available |
PharmGKB | PA32 |
KEGG | hsa:142 |
BioCyc | Not available |
Entrez Gene (GeneID) | 142 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9866 | 6.7689 × 10-4 |
Accuracy | 0.9503 | 0.0016 |
Sensitivity | 0.9567 | 0.0028 |
Specificity | 0.9431 | 0.0018 |
BEDROC | 0.9995 | 3.1522 × 10-4 |
MCC Threshold | 0.564 | N/A |
MCC | 0.9011 | N/A |
F-score Threshold | 0.542 | N/A |
F-score | 0.9534 | N/A |