TargetNet
P09483
Neuronal acetylcholine receptor subunit alpha-4
Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.
Database Links
| Database | Links |
|---|---|
| UniProt | P09483 |
| PDB | 1OLE |
| BioGrid | Not available |
| BindingDB | P09483 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 465 |
| PharmGKB | Not available |
| KEGG | rno:25590 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 25590 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.963 | 0.0031 |
| Accuracy | 0.9357 | 0.0086 |
| Sensitivity | 0.9523 | 0.0076 |
| Specificity | 0.9157 | 0.0158 |
| BEDROC | 0.9536 | 0.0172 |
| MCC Threshold | 0.47 | N/A |
| MCC | 0.8703 | N/A |
| F-score Threshold | 0.47 | N/A |
| F-score | 0.9419 | N/A |