TargetNet
P08913
Alpha-2A adrenergic receptor
Function
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.
Database Links
| Database | Links |
|---|---|
| UniProt | P08913 |
| PDB | 1HLL, 1HO9, 1HOD, 1HOF |
| BioGrid | 106659 |
| BindingDB | P08913 |
| DrugBank | DB00321, DB00182, DB00964, DB00865, DB00217, DB00484, DB00575, DB04840, DB00633, DB00449, DB00751, DB00696, DB00800, DB00629, DB00226, DB01170, DB01018, DB04948, DB00968, DB06148, DB00370, DB00368, DB00935, DB00692, DB00397, DB00852, DB00697, DB00656, DB01392 |
| Guide to PHARMACOLOGY | 25 |
| PharmGKB | PA35 |
| KEGG | hsa:150 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 150 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9372 | 0.004 |
| Accuracy | 0.8755 | 0.0035 |
| Sensitivity | 0.895 | 0.0054 |
| Specificity | 0.8514 | 0.0051 |
| BEDROC | 0.9943 | 0.0021 |
| MCC Threshold | 0.452 | N/A |
| MCC | 0.7745 | N/A |
| F-score Threshold | 0.452 | N/A |
| F-score | 0.9021 | N/A |