5-hydroxytryptamine receptor 2C
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1- 2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and feeding behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.
Database | Links |
---|---|
UniProt | P08909 |
PDB | Not available |
BioGrid | Not available |
BindingDB | P08909 |
DrugBank | Not available |
Guide to PHARMACOLOGY | 8 |
PharmGKB | Not available |
KEGG | rno:25187 |
BioCyc | Not available |
Entrez Gene (GeneID) | 25187 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9252 | 0.0038 |
Accuracy | 0.8663 | 0.0045 |
Sensitivity | 0.8636 | 0.0067 |
Specificity | 0.8689 | 0.0073 |
BEDROC | 0.9619 | 0.0091 |
MCC Threshold | 0.474 | N/A |
MCC | 0.7365 | N/A |
F-score Threshold | 0.39 | N/A |
F-score | 0.87 | N/A |