5-hydroxytryptamine receptor 1A
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
Database | Links |
---|---|
UniProt | P08908 |
PDB | Not available |
BioGrid | 109582 |
BindingDB | P08908 |
DrugBank | DB00866, DB01238, DB00490, DB00363, DB00216, DB01049, DB00176, DB00589, DB00247, DB00370, DB00960, DB00571, DB01224, DB01104, DB01079, DB00656, DB00285, DB00246 |
Guide to PHARMACOLOGY | 1 |
PharmGKB | PA192 |
KEGG | hsa:3350 |
BioCyc | Not available |
Entrez Gene (GeneID) | 3350 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9661 | 7.3953 × 10-4 |
Accuracy | 0.9202 | 0.0019 |
Sensitivity | 0.9138 | 0.0033 |
Specificity | 0.9261 | 0.0016 |
BEDROC | 0.9743 | 0.0025 |
MCC Threshold | 0.528 | N/A |
MCC | 0.8374 | N/A |
F-score Threshold | 0.43 | N/A |
F-score | 0.9168 | N/A |