TargetNet
P08709
Coagulation factor VII
Function
Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
Database Links
| Database | Links |
|---|---|
| UniProt | P08709 |
| PDB | 1BF9, 1CVW, 1DAN, 1DVA, 1F7E, 1F7M, 1FAK, 1FF7, 1FFM, 1J9C, 1JBU, 1KLI, 1KLJ, 1NL8, 1O5D, 1QFK, 1W0Y, 1W2K, 1W7X, 1W8B, 1WQV, 1WSS, 1WTG, 1WUN, 1WV7, 1YGC, 1Z6J, 2A2Q, 2AEI, 2AER, 2B7D, 2B8O, 2BZ6, 2C4F, 2EC9, 2F9B, 2FIR, 2FLB, 2FLR, 2PUQ, 2ZP0, 2ZWL, 2ZZU, 3ELA, 3TH2, 3TH3, 3TH4, 4ISH, 4ISI, 4JYU, 4JYV, 4JZD, 4JZE, 4JZF, 4NG9, 4NGA |
| BioGrid | 108453 |
| BindingDB | P08709 |
| DrugBank | DB00100, DB00036, DB00170 |
| Guide to PHARMACOLOGY | 2363 |
| PharmGKB | PA160 |
| KEGG | hsa:2155 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 2155 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9747 | 0.0022 |
| Accuracy | 0.9429 | 0.0033 |
| Sensitivity | 0.972 | 0.0035 |
| Specificity | 0.9074 | 0.0054 |
| BEDROC | 0.9881 | 0.0043 |
| MCC Threshold | 0.432 | N/A |
| MCC | 0.8927 | N/A |
| F-score Threshold | 0.432 | N/A |
| F-score | 0.9526 | N/A |