TargetNet
P08588
Beta-1 adrenergic receptor
Function
Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.
Database Links
| Database | Links |
|---|---|
| UniProt | P08588 |
| PDB | 2LSQ |
| BioGrid | 106662 |
| BindingDB | P08588 |
| DrugBank | DB01193, DB00866, DB01118, DB01102, DB00335, DB00195, DB01295, DB00612, DB01158, DB00521, DB01136, DB01151, DB00841, DB00988, DB00668, DB00187, DB00221, DB01064, DB00598, DB01210, DB01214, DB00264, DB01203, DB00368, DB01580, DB01359, DB00960, DB01297, DB00571, DB00734, DB00373, DB00246 |
| Guide to PHARMACOLOGY | 28 |
| PharmGKB | PA38 |
| KEGG | hsa:153 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 153 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.961 | 7.6581 × 10-4 |
| Accuracy | 0.9088 | 0.0027 |
| Sensitivity | 0.9028 | 0.0059 |
| Specificity | 0.9147 | 0.0059 |
| BEDROC | 0.9896 | 0.0038 |
| MCC Threshold | 0.302 | N/A |
| MCC | 0.8253 | N/A |
| F-score Threshold | 0.302 | N/A |
| F-score | 0.9145 | N/A |