Receptor-type tyrosine-protein phosphatase C
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
Database | Links |
---|---|
UniProt | P08575 |
PDB | 1YGR, 1YGU |
BioGrid | 111752 |
BindingDB | P08575 |
DrugBank | Not available |
Guide to PHARMACOLOGY | 1852 |
PharmGKB | PA34011 |
KEGG | hsa:5788 |
BioCyc | Not available |
Entrez Gene (GeneID) | 5788 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9176 | 0.0072 |
Accuracy | 0.856 | 0.0117 |
Sensitivity | 0.8355 | 0.022 |
Specificity | 0.8733 | 0.012 |
BEDROC | 0.9723 | 0.0078 |
MCC Threshold | 0.432 | N/A |
MCC | 0.7178 | N/A |
F-score Threshold | 0.432 | N/A |
F-score | 0.8496 | N/A |