Integrin alpha-IIb
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Database | Links |
---|---|
UniProt | P08514 |
PDB | 1DPK, 1DPQ, 1JX5, 1KUP, 1KUZ, 1M8O, 1RN0, 1S4W, 1TYE, 1UV9, 2K1A, 2K9J, 2KNC, 2VC2, 2VDK, 2VDL, 2VDM, 2VDN, 2VDO, 2VDP, 2VDQ, 2VDR, 3FCS, 3FCU, 3NID, 3NIF, 3NIG, 3T3M, 3T3P, 3ZDX, 3ZDY, 3ZDZ, 3ZE0, 3ZE1, 3ZE2, 4CAK |
BioGrid | 109881 |
BindingDB | P08514 |
DrugBank | DB00775 |
Guide to PHARMACOLOGY | Not available |
PharmGKB | PA29938 |
KEGG | hsa:3674 |
BioCyc | Not available |
Entrez Gene (GeneID) | 3674 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9433 | 0.0025 |
Accuracy | 0.8816 | 0.0034 |
Sensitivity | 0.9084 | 0.0045 |
Specificity | 0.8524 | 0.0046 |
BEDROC | 0.9775 | 0.0039 |
MCC Threshold | 0.484 | N/A |
MCC | 0.7692 | N/A |
F-score Threshold | 0.484 | N/A |
F-score | 0.8923 | N/A |