Muscarinic acetylcholine receptor M3
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Database | Links |
---|---|
UniProt | P08483 |
PDB | 2AMK, 4DAJ |
BioGrid | Not available |
BindingDB | P08483 |
DrugBank | Not available |
Guide to PHARMACOLOGY | 15 |
PharmGKB | Not available |
KEGG | rno:24260 |
BioCyc | Not available |
Entrez Gene (GeneID) | 24260 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9263 | 0.0062 |
Accuracy | 0.8308 | 0.0109 |
Sensitivity | 0.8391 | 0.0174 |
Specificity | 0.8211 | 0.0223 |
BEDROC | 0.9993 | 6.2058 × 10-4 |
MCC Threshold | 0.646 | N/A |
MCC | 0.692 | N/A |
F-score Threshold | 0.326 | N/A |
F-score | 0.8467 | N/A |