TargetNet
P08473
Neprilysin
Function
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV- inducible elastase activity toward skin preelastic and elastic fibers.
Database Links
| Database | Links |
|---|---|
| UniProt | P08473 |
| PDB | 1DL9, 1DMT, 1QVD, 1R1H, 1R1I, 1R1J, 1Y8J, 2QPJ, 2YB9 |
| BioGrid | 110455 |
| BindingDB | P08473 |
| DrugBank | DB00616 |
| Guide to PHARMACOLOGY | 1611 |
| PharmGKB | PA30864 |
| KEGG | hsa:4311 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 4311 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9749 | 0.0017 |
| Accuracy | 0.9237 | 0.0049 |
| Sensitivity | 0.9397 | 0.0061 |
| Specificity | 0.906 | 0.006 |
| BEDROC | 0.9978 | 9.342 × 10-4 |
| MCC Threshold | 0.426 | N/A |
| MCC | 0.8639 | N/A |
| F-score Threshold | 0.426 | N/A |
| F-score | 0.9365 | N/A |